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What is the difference between sertraline and mirtazapine? Remeron (mirtazapine) and Zoloft (sertraline) are antidepressants used to treat depression, anxiety, and posttraumatic stress disorder (PTSD). Remeron and Zoloft belong to different drug classes. Remeron is a tetracyclic antidepressant and Zoloft is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Does mirtazapine cause anxiety? Mirtazapine (Remeron) has a much more sedating effect, generally reducing its potential to aggravate initial anxiety. Mirtazapine may cause residual morning sedation that often improves with continued therapy and may cause an increase in appetite or weight gain.
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