Which drug is considered first line treatment for partial and tonic clonic seizures? NICE 2016 guidelines recommend carbamazepine or lamotrigine as first - line treatment for children, young people and adults with newly diagnosed partial seizures. If not tolerated then levetiracetam, oxcarbazepine or sodium valproate can be used. How much Keppra can you take? The usual starting dose is 500 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 3000 mg per day. Can epilepsy affect periods? Because of the changes in hormone levels that happen throughout the menstrual cycle, one in three women with epilepsy finds that their seizures are affected by their periods. Some women regularly have their seizures at a particular time during their menstrual cycle.
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